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Article

Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes.

Developmental neuroscience - 1 Jan 2011

Keck-Wherley Jennifer, Grover Deepak, Bhattacharyya Sharmistha, Xu Xiufen, Holman Derek, Lombardini Eric D, Verma Ranjana, Biswas Roopa, Galdzicki Zygmunt

Abstract excerpt

Down syndrome (DS; trisomy 21) is one of the most common genetic causes of intellectual disability, which is attributed to triplication of genes located on chromosome 21. Elevated levels of several microRNAs (miRNAs) located on chromosome 21 have been reported in human DS heart and brain tissues. The Ts65Dn mouse model is the most investigated DS model with a triplicated segment of mouse chromosome 16 harboring...

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Identifiers

PMID: 22042248
DOI: 10.1159/000330884
PMCID: PMC3254042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes.PMID 22042248Read ↗

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