Article
The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome.
American journal of medical genetics. Part A - 1 Sept 2015
Guedj Faycal, Pennings Jeroen L A, Ferres Millie A, Graham Leah C, Wick Heather C, Miczek Klaus A, Slonim Donna K, Bianchi Diana W
Abstract excerpt
Human fetuses with Down syndrome demonstrate abnormal brain growth and reduced neurogenesis. Despite the prenatal onset of the phenotype, most therapeutic trials have been conducted in adults. Here, we present evidence for fetal brain molecular and neonatal behavioral alterations in the Ts1Cje mouse model of Down syndrome. Embryonic day 15.5 brain hemisphere RNA from Ts1Cje embryos (n = 5) and wild type...
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