Article
Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2000
Richtsmeier J T, Baxter L L, Reeves R H
Abstract excerpt
Mouse genetic models can be used to dissect molecular mechanisms that result in human disease. This approach requires detection and demonstration of compelling parallels between phenotypes in mouse and human. Ts65Dn mice are at dosage imbalance for many of the same genes duplicated in trisomy 21 or Down syndrome (DS), the most common live-born human aneuploidy. Analysis of the craniofacial skeleton of Ts65Dn mice...
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