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Article

Effects of aneuploidy on skull growth in a mouse model of Down syndrome

12 Mar 2007

Abstract excerpt

Adult craniofacial morphology results from complex interactions among genetic, epigenetic and environmental factors. Trisomy causes perturbations in the genetic programmes that control development and these are reflected in morphology that can either ameliorate or worsen with time and growth. Many of the specific changes that occur in Down syndrome can be studied in the Ts65Dn trisomic mouse, which shows direct...

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PMID: 17428201
DOI: 10.1111/j.1469-7580.2007.00705.x

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