Article

Molecular Cartography of the Human and Mouse Down Syndrome Brain

2024-11-15

Abstract excerpt

<title>Abstract</title> <p>Down syndrome (DS, or Trisomy 21) is one of the most common genetic causes of intellectual disability. DS results in both abnormal neurodevelopment and accelerated neurodegeneration, but the molecular mechanisms underlying abnormal cortical construction and aging are incompletely understood. To gain molecular insight into the prenatal neurobiology of DS, we performed single-nucleus sequ...

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Literature Corpus work: cdd33400-0905-50d2-a817-764d772f5e0b
DOI: 10.21203/rs.3.rs-5374449/v1

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