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Article

Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2010

Blazek Joshua D, Billingsley Cherie N, Newbauer Abby, Roper Randall J

Abstract excerpt

Trisomy 21 results in Down syndrome (DS) and causes phenotypes that may result from alterations of developmental processes. The Ts65Dn mouse is the most widely used genetic and phenotypic model for DS. We used over 1,500 offspring from Ts65Dn and two nontrisomic genetically similar control strains to investigate the influence of trisomy on developmental alterations and number of offspring. For the first time, we...

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PMID: 20503361
DOI: 10.1002/dvdy.22295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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