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Article

Hyper-activation of the target of rapamycin (Tor) kinase 1 decreases intracellular glutathione content in Saccharomyces cerevisiae as revealed by LC-MS/MS analysis.

Bioscience, biotechnology, and biochemistry - 1 Jan 2013

Oku Masahide, Ichiki Yayoi, Shiraishi Akiko, Takahara Terunao, Maeda Tatsuya, Sakai Yasuyoshi

Abstract excerpt

The targets of rapamycin (Tor) kinases play central roles in the integrated regulation of cellular activities. Although the molecular mechanisms of Tor-mediated signaling pathways have been studied extensively in yeast, the relationship between kinase activity and the redox maintenance system remains obscure. In this study, we established a quantitative extraction and determination method for glutathione-related...

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PMID: 23832372
DOI: 10.1271/bbb.130314

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