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Article

Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Jan 2005

Perrone Gabriel G, Grant Chris M, Dawes Ian W

Abstract excerpt

Glutathione is an essential metabolite protecting cells against oxidative stress and aging. Here, we show that endogenously synthesized glutathione undergoes intercellular cycling during growth to stationary phase. Genome-wide screening identified approximately 270 yeast deletion mutants that overexcrete glutathione, predominantly in the reduced form, and identified a surprising set of functions important for...

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PMID: 15509654
DOI: 10.1091/mbc.e04-07-0560
PMCID: PMC539166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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