A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth.

doi:10.1091/mbc.7.11.1805

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Article

A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth.

Molecular biology of the cell - 1 Nov 1996

Muller E G

Abstract excerpt

A glutathione reductase null mutant of Saccharomyces cerevisiae was isolated in a synthetic lethal genetic screen for mutations which confer a requirement for thioredoxin. Yeast mutants that lack glutathione reductase (glr1 delta) accumulate high levels of oxidized glutathione and have a twofold...

Topics

Diamide
Genes, Fungal
Glutathione
Glutathione Reductase
Membrane Proteins
Mutation
Oxidation-Reduction
Peroxiredoxins
Phenotype
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sulfhydryl Reagents
Thioredoxins

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