A genome-wide screen in yeast identifies specific oxidative stress genes required for the maintenance of sub-cellular redox homeostasis.

doi:10.1371/journal.pone.0044278

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Article

A genome-wide screen in yeast identifies specific oxidative stress genes required for the maintenance of sub-cellular redox homeostasis.

PloS one - 1 Jan 2012

Ayer Anita, Fellermeier Sina, Fife Christopher, Li Simone S, Smits Gertien, Meyer Andreas J, Dawes Ian W, Perrone Gabriel G

Abstract excerpt

Maintenance of an optimal redox environment is critical for appropriate functioning of cellular processes and cell survival. Despite the importance of maintaining redox homeostasis, it is not clear how the optimal redox potential is sensed and set, and the processes that impact redox on a cellular/organellar level are poorly understood. The genetic bases of cellular redox homeostasis were investigated using a...

Topics

Antioxidants
Cytosol
Gene Deletion
Gene Library
Genes, Fungal
Genetic Testing
Green Fluorescent Proteins
Homeostasis
Mitochondria
Molecular Probes
Molecular Sequence Annotation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidation-Reduction

Oxidative Stress

Peroxisomes

Phenotype

Promoter Regions, Genetic

Reproducibility of Results

Saccharomyces cerevisiae

Source

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Identifiers

PMID: 22970195
DOI: 10.1371/journal.pone.0044278
PMCID: PMC3435413

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