Article

Manganese is a Physiologically Relevant TORC1 Activator in Yeast and Mammals

2021-12-09

Abstract excerpt

The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human diseases. Whether intracellular Mn levels may be sensed and modulate intracellular signaling events has so far remained largely unexplored. The highly conserved target of rapamycin complex 1 (TORC1, mTORC1 in mammals) protein kinase requires divalent metal cofactors such as magnesium (Mg 2+...

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Literature Corpus work: 907ec12b-7227-550c-bd06-f84d26344a7c
DOI: 10.1101/2021.12.09.471923

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