Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The yeast autophagy protease Atg4 is regulated by thioredoxin.

Autophagy - 1 Jan 2014

Pérez-Pérez María Esther, Zaffagnini Mirko, Marchand Christophe H, Crespo José L, Lemaire Stéphane D

Abstract excerpt

Autophagy is a membrane-trafficking process whereby double-membrane vesicles called autophagosomes engulf and deliver intracellular material to the vacuole for degradation. Atg4 is a cysteine protease with an essential function in autophagosome formation. Mounting evidence suggests that reactive oxygen species may play a role in the control of autophagy and could regulate Atg4 activity but the precise mechanisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Autophagy-Related Protein 8 Family
Share to Autophagy-Related Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cysteine

Share to Disulfides

Share to Microtubule-Associated Proteins

Share to Phagosomes

Share to Thioredoxins

Source

Open in PubMed Open full text

Identifiers

PMID: 25483965
DOI: 10.4161/auto.34396
PMCID: PMC4502779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The yeast autophagy protease Atg4 is regulated by thioredoxin.PMID 25483965Read ↗

The protease activity of human ATG4B is regulated by reversible oxidative modification.Semantic proximity Read ↗

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.Semantic proximity Read ↗

Control of Autophagy in Chlamydomonas Is Mediated through Redox-Dependent Inactivation of the ATG4 Protease.Semantic proximity Read ↗

Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic InterventionsSemantic proximity Read ↗

The Role of Free Radicals in Autophagy Regulation: Implications for AgeingSemantic proximity Read ↗

Disruption of Redox Homeostasis by Enzymatic Activation of a Triakylphosphine Probe in MitochondriaSemantic proximity Read ↗

The roles of thiol oxidoreductases in yeast replicative aging.Semantic proximity Read ↗

Enhancing autophagy by redox regulation extends lifespan in DrosophilaSemantic proximity Read ↗

Atg27 is required for autophagy-dependent cycling of Atg9.Semantic proximity Read ↗

Endoplasmic reticulum (ER) stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant.Semantic proximity Read ↗

Hyper-activation of the target of rapamycin (Tor) kinase 1 decreases intracellular glutathione content in Saccharomyces cerevisiae as revealed by LC-MS/MS analysis.Semantic proximity Read ↗

Tsa1 is the dominant peroxide scavenger and a source of H2O2-dependent GSSG production in yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.