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Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulation.

Molecular microbiology - 1 Jul 1996

Grant C M, Collinson L P, Roe J H, Dawes I W

Abstract excerpt

Glutathione (GSH) is an abundant cellular thiol which has been implicated in many cellular processes including protection against xenobiotics, carcinogens and free radicals. Utilization of GSH in both enzymic and non-enzymic defence mechanisms results in its conversion to the oxidized form (GSSG), and it must be recycled to GSH to maintain the high intracellular ratio of GSH to GSSG. Glutathione reductase (GLR)...

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PMID: 8843443
DOI: 10.1046/j.1365-2958.1996.6351340.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulation.PMID 8843443Read ↗

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Glutathione and catalase provide overlapping defenses for protection against hydrogen peroxide in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Glutathione, but not transcription factor Yap1, is required for carbon source-dependent resistance to oxidative stress in Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast mitochondrial glutathione is an essential antioxidant with mitochondrial thioredoxin providing a back-up system.Semantic proximity Read ↗

A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth.Semantic proximity Read ↗

Saccharomyces cerevisiae exhibits a yAP-1-mediated adaptive response to malondialdehyde.Semantic proximity Read ↗

Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of yeast glutaredoxins as glutathione S-transferases.Semantic proximity Read ↗

Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae.Semantic proximity Read ↗

Involvement of glutathione transferases, Gtt1and Gtt2, with oxidative stress response generated by H2O2 during growth of Saccharomyces cerevisiae.Semantic proximity Read ↗

Thioredoxins are required for protection against a reductive stress in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity.Semantic proximity Read ↗

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