Article
Metabolic changes underlying the higher accumulation of glutathione in Saccharomyces cerevisiae mutants.
Applied microbiology and biotechnology - 1 Feb 2011
Nisamedtinov Ildar, Kevvai Kaspar, Orumets Kerti, Arike Liisa, Sarand Inga, Korhola Matti, Paalme Toomas
Abstract excerpt
Molecular mechanisms leading to glutathione (GSH) over-accumulation in a Saccharomyces cerevisiae strain produced by UV irradiation-induced random mutagenesis were studied. The mutant accumulated GSH but also cysteine and γ-glutamylcysteine in concentrations that were several fold higher than in its wild-type parent strain under all studied cultivation conditions (chemostat, fed-batch, and turbidostat)....
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