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Article

Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Apr 2006

Bertolino Alessandro, Blasi Giuseppe, Latorre Valeria, Rubino Valeria, Rampino Antonio, Sinibaldi Lorenzo, Caforio Grazia, Petruzzella Vittoria, Pizzuti Antonio, Scarabino Tommaso, Nardini Marcello, Weinberger Daniel R, Dallapiccola Bruno

Abstract excerpt

Functional polymorphisms in the catechol-O-methyltransferase (COMT) and the dopamine transporter (DAT) genes modulate dopamine inactivation, which is crucial for determining neuronal signal-to-noise ratios in prefrontal cortex during working memory. We show that the COMT Met158 allele and the DAT...

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Identifiers

PMID: 16611807
DOI: 10.1523/JNEUROSCI.4975-05.2006
PMCID: PMC6673886

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16611807-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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