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Article

Effects of tolcapone on working memory and brain activity in abstinent smokers: a proof-of-concept study.

Drug and alcohol dependence - 15 Dec 2013

Ashare Rebecca L, Wileyto E Paul, Ruparel Kosha, Goelz Patricia M, Hopson Ryan D, Valdez Jeffrey N, Gur Ruben C, Loughead James, Lerman Caryn

Abstract excerpt

BACKGROUND: Dopamine levels in the prefrontal cortex (PFC) are thought to play an important role in cognitive function and nicotine dependence. The catechol-O-methyltransferase (COMT) inhibitor tolcapone, an FDA-approved treatment for Parkinson's disease, increases prefrontal dopamine levels, with cognitive benefits that may vary by COMT genotype. We tested whether tolcapone alters working memory-related brain...

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Source

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Identifiers

PMID: 24095246
DOI: 10.1016/j.drugalcdep.2013.09.003
PMCID: PMC3960598

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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