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Article

EVI1 dysregulation: impact on biology and therapy of myeloid malignancies.

Blood cancer journal - 22 Mar 2021

Birdwell Christine, Fiskus Warren, Kadia Tapan M, DiNardo Courtney D, Mill Christopher P, Bhalla Kapil N

Abstract excerpt

Ecotropic viral integration site 1 (Evi1) was discovered in 1988 as a common site of ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic zinc-finger transcription factor whose overexpression contributes to disease progression and an aggressive phenotype, correlating with poor clinical outcome in myeloid malignancies. Despite progress in understanding the biology of EVI1...

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Share to Acute Myeloid Leukemia Research
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genomic Instability

Share to Leukemia, Myeloid

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Share to Protein Processing, Post-Translational

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Source

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Identifiers

PMID: 33753715
DOI: 10.1038/s41408-021-00457-9
PMCID: PMC7985498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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EVI1 dysregulation: impact on biology and therapy of myeloid malignancies.PMID 33753715Read ↗

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