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Article

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations.

Blood - 1 Jan 2015

Lavallée Vincent-Philippe, Gendron Patrick, Lemieux Sébastien, D'Angelo Giovanni, Hébert Josée, Sauvageau Guy

Abstract excerpt

The genetic and transcriptional signature of EVI1 (ecotropic viral integration site 1)-rearranged (EVI1-r) acute myeloid leukemias (AMLs) remains poorly defined. We performed RNA sequencing of 12 EVI1-r AMLs and compared the results with those of other AML subtypes (n = 139) and normal CD34(+) cells (n = 17). Results confirm high frequencies of RAS and other activated signaling mutations (10/12 AMLs) and identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25331116
DOI: 10.1182/blood-2014-07-591529
PMCID: PMC4358966

Genes

IKZF1
MECOM
MYCT1
PAWR
PREX2
VIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations.PMID 25331116Read ↗

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