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Article

EVI1 controls proliferation in acute myeloid leukaemia through modulation of miR-1-2

14 Sept 2010

Abstract excerpt

BACKGROUND: The EVI1(ecotropic virus integration site 1) gene codes for a zinc-finger transcription factor, whose transcriptional activation leads to a particularly aggressive form of acute myeloid leukaemia (AML). Although, EVI1 interactions with key proteins in hematopoiesis have been previously described, the precise role of this transcription factor in promoting leukaemic transformation is not completely...

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PMID: 20842122
DOI: 10.1038/sj.bjc.6605874

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EVI1 controls proliferation in acute myeloid leukaemia through modulation of miR-1-2PMID 20842122Read ↗

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EVI1 drives leukemogenesis through aberrant ERG activationSemantic proximity Read ↗

Evi1 forms a bridge between the epigenetic machinery and signaling pathwaysSemantic proximity Read ↗

Repression of RUNX1 Activity by EVI1: A New Role of EVI1 in LeukemogenesisSemantic proximity Read ↗

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EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemiaSemantic proximity Read ↗

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