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Article

EVI1-mediated Programming of Normal and Malignant Hematopoiesis

1 Oct 2023

Abstract excerpt

Ecotropic viral integration site 1 (EVI1), encoded at the MECOM locus, is an oncogenic zinc finger transcription factor with diverse roles in normal and malignant cells, most extensively studied in the context of hematopoiesis. EVI1 interacts with other transcription factors in a context-dependent manner and regulates transcription and chromatin remodeling, thereby influencing the proliferation, differentiation,...

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PMID: 37810550
DOI: 10.1097/hs9.0000000000000959

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