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Article

Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics.

Circulation research - 13 Sept 2013

Shimasaki Yukio, Pan Ning, Messina Louis M, Li Chunying, Chen Kai, Liu Lijun, Cooper Marcus P, Vita Joseph A, Keaney John F

Abstract excerpt

RATIONALE: Mitochondria, although required for cellular ATP production, are also known to have other important functions that may include modulating cellular responses to environmental stimuli. However, the mechanisms whereby mitochondria impact cellular phenotype are not yet clear. OBJECTIVE: To determine how mitochondria impact endothelial cell function. METHODS AND RESULTS: We report here that stimuli for...

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Identifiers

PMID: 23819990
DOI: 10.1161/CIRCRESAHA.113.301319
PMCID: PMC3869454

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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