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Article

Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension.

American journal of respiratory cell and molecular biology - 1 Jul 2016

Plecitá-Hlavatá Lydie, Tauber Jan, Li Min, Zhang Hui, Flockton Amanda R, Pullamsetti Soni Savai, Chelladurai Prakash, D'Alessandro Angelo, El Kasmi Karim C, Ježek Petr, Stenmark Kurt R

Abstract excerpt

Remodeling of the distal pulmonary artery wall is a characteristic feature of pulmonary hypertension (PH). In hypoxic PH, the most substantial pathologic changes occur in the adventitia. Here, there is marked fibroblast proliferation and profound macrophage accumulation. These PH fibroblasts (PH-Fibs) maintain a hyperproliferative, apoptotic-resistant, and proinflammatory phenotype in ex vivo culture. Considering...

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Identifiers

PMID: 26699943
DOI: 10.1165/rcmb.2015-0142OC
PMCID: PMC4942204

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NDUFS4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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