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Article

SOD2 and the Mitochondrial UPR: Partners Regulating Cellular Phenotypic Transitions.

Trends in biochemical sciences - 1 Jul 2016

He Chenxia, Hart Peter C, Germain Doris, Bonini Marcelo G

Abstract excerpt

ATP and reactive oxygen species (ROS) are signaling molecules that control cellular function and phenotype. Mitochondria produce both ATP and ROS. Since the electrons needed to generate either ATP or ROS originate from NADH/FADH2, the mechanism through which electrons flow towards oxygen determines yields and whether ATP or ROS prevails. Alterations in the electron flow impact cells dramatically, such as by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27180143
DOI: 10.1016/j.tibs.2016.04.004
PMCID: PMC4930371

Genes

SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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