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Article

Regulation of cellular oncosis by uncoupling protein 2.

The Journal of biological chemistry - 26 Jul 2002

Mills Edward M, Xu Dong, Fergusson Maria M, Combs Christian A, Xu Yuhui, Finkel Toren

Abstract excerpt

Cell death can proceed through at least two distinct pathways. Apoptosis is an energy-dependent process characterized morphologically by cell shrinkage, whereas oncosis is a form of cell death induced by energy depletion and initially characterized by cell swelling. We demonstrate in HeLa cells but not in normal diploid fibroblasts that modest increases in the expression level of uncoupling protein 2 (UCP-2)...

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Identifiers

PMID: 12011039
DOI: 10.1074/jbc.M111860200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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