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Article

The mitochondrial permeability transition pore regulates endothelial bioenergetics and angiogenesis.

Circulation research - 10 Apr 2015

Marcu Raluca, Kotha Surya, Zhi Zhongwei, Qin Wan, Neeley Christopher K, Wang Ruikang K, Zheng Ying, Hawkins Brian J

Abstract excerpt

RATIONALE: The mitochondrial permeability transition pore is a well-known initiator of cell death that is increasingly recognized as a physiological modulator of cellular metabolism. OBJECTIVE: We sought to identify how the genetic deletion of a key regulatory subunit of the mitochondrial permeability transition pore, cyclophilin D (CypD), influenced endothelial metabolism and intracellular signaling. METHODS AND...

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Source

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Identifiers

PMID: 25722455
DOI: 10.1161/CIRCRESAHA.116.304881
PMCID: PMC4393786

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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