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Article

BET proteins promote efficient murine leukemia virus integration at transcription start sites

1 Jul 2013

Abstract excerpt

The selection of chromosomal targets for retroviral integration varies markedly, tracking with the genus of the retrovirus, suggestive of targeting by binding to cellular factors. γ-Retroviral murine leukemia virus (MLV) DNA integration into the host genome is favored at transcription start sites, but the underlying mechanism for this preference is unknown. Here, we have identified bromodomain and extraterminal...

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PMID: 23818621
DOI: 10.1073/pnas.1307157110

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