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Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure

7 Jan 2021

Abstract excerpt

Following reverse transcription, HIV viral DNA is integrated into host cell genomes and establishes a stable latent infection, which has posed a major obstacle for obtaining a cure for HIV. HIV proviral transcription is regulated in cellular reservoirs by complex host epigenetic and transcriptional machineries. The Bromodomain (BD) and Extra-Terminal Domain (ET) protein, BRD4, is an important epigenetic reader...

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PMID: 33413475
DOI: 10.1186/s12977-020-00547-9

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