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Article

Enhancers Are Major Targets for Murine Leukemia Virus Vector Integration

6 Feb 2014

Abstract excerpt

UNLABELLED: Retroviral vectors have been used in successful gene therapies. However, in some patients, insertional mutagenesis led to leukemia or myelodysplasia. Both the strong promoter/enhancer elements in the long terminal repeats (LTRs) of murine leukemia virus (MLV)-based vectors and the vector-specific integration site preferences played an important role in these adverse clinical events. MLV integration is...

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PMID: 24501411
DOI: 10.1128/jvi.00011-14

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