Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction

12 Mar 2014

Abstract excerpt

We report alterations to the murine leukemia virus (MLV) integrase (IN) protein that successfully result in decreasing its integration frequency at transcription start sites and CpG islands, thereby reducing the potential for insertional activation. The host bromo and extraterminal (BET) proteins Brd2, 3 and 4 interact with the MLV IN protein primarily through the BET protein ET domain. Using solution NMR,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24623816
DOI: 10.1093/nar/gku175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interactionPMID 24623816Read ↗

BET proteins promote efficient murine leukemia virus integration at transcription start sitesSemantic proximity Read ↗

Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus IntegrationSemantic proximity Read ↗

Analysis of mutations in the integration function of Moloney murine leukemia virus: effects on DNA binding and cutting.Semantic proximity Read ↗

Enhancers Are Major Targets for Murine Leukemia Virus Vector IntegrationSemantic proximity Read ↗

Revealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteins.Semantic proximity Read ↗

A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeatsSemantic proximity Read ↗

The Molecular Biology of HIV IntegraseSemantic proximity Read ↗

Mechanistic insights and <i>in vivo</i> HIV suppression by the BRD4-targeting small molecule ZL0580Semantic proximity Read ↗

Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion MorphogenesisSemantic proximity Read ↗

Mutations in the catalytic core or the C-terminus of murine leukemia virus (MLV) integrase disrupt virion infectivity and exert diverse effects on reverse transcription.Semantic proximity Read ↗

Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs.Semantic proximity Read ↗

Molecular mechanisms of HIV integration and therapeutic interventionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.