Mechanistic insights and <i>in vivo</i> HIV suppression by the BRD4-targeting small molecule ZL0580

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic suppression and durable silencing of HIV represent a promising strategy to achieve ART-free remission, consistent with the “block and lock” HIV cure paradigm. BRD4 is a host epigenetic reader and plays a critical role in HIV transcriptional regulation. We previously identified ZL0580, a first-in-class BRD4-selective small molecule distinct from the pan-BET inhibitor JQ1, which induces...

Topics

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• Azepines
• Cell Cycle Proteins
• Chromatin
• HIV/AIDS drug development and treatment
• HIV Research and Treatment
• Multiple Myeloma Research and Treatments
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

846aaf50-85e3-579d-b6a3-c6e0c95b0911

DOI

10.1101/2025.08.14.670267