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Article

Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation.

The Journal of biological chemistry - 9 Aug 2013

Schlam Daniel, Bohdanowicz Michal, Chatgilialoglu Alexandros, Chatilialoglu Alexandros, Steinberg Benjamin E, Ueyama Takehiko, Du Guangwei, Grinstein Sergio, Fairn Gregory D

Abstract excerpt

It is commonly assumed that all phagosomes have identical molecular composition. This assumption has remained largely unchallenged due to a paucity of methods to distinguish individual phagosomes. We devised an assay that extends the utility of nitro blue tetrazolium for detection and quantification of NAPDH oxidase (NOX) activity in individual phagosomes. Implementation of this assay revealed that in murine...

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Identifiers

PMID: 23814057
DOI: 10.1074/jbc.M113.457606
PMCID: PMC3743482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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