Article
Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2013
Grimm Melissa J, Vethanayagam R Robert, Almyroudis Nikolaos G, Dennis Carly G, Khan A Nazmul H, D'Auria Anthony C, Singel Kelly L, Davidson Bruce A, Knight Paul R, Blackwell Timothy S, Hohl Tobias M, Mansour Michael K, Vyas Jatin M, Röhm Marc, Urban Constantin F, Kelkka Tiina, Holmdahl Rikard, Segal Brahm H
Abstract excerpt
Chronic granulomatous disease, an inherited disorder of the NADPH oxidase in which phagocytes are defective in the generation of superoxide anion and downstream reactive oxidant species, is characterized by severe bacterial and fungal infections and excessive inflammation. Although NADPH oxidase isoforms exist in several lineages, reactive oxidant generation is greatest in neutrophils, where NADPH oxidase has...
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