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Article

The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis.

The Journal of experimental medicine - 7 Aug 2006

Suh Chang-Il, Stull Natalie D, Li Xing Jun, Tian Wei, Price Marianne O, Grinstein Sergio, Yaffe Michael B, Atkinson Simon, Dinauer Mary C

Abstract excerpt

Superoxide produced by the phagocyte reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is essential for host defense. Enzyme activation requires translocation of p67(phox), p47(phox), and Rac-GTP to flavocytochrome b558 in phagocyte membranes. To examine the regulation of phagocytosis-induced superoxide production, flavocytochrome b558, p47(phox), p67(phox), and the FcgammaIIA receptor were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16880255
DOI: 10.1084/jem.20052085
PMCID: PMC2118377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis.PMID 16880255Read ↗

Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome.Semantic proximity Read ↗

Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production.Semantic proximity Read ↗

The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.Semantic proximity Read ↗

Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding.Semantic proximity Read ↗

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The Rac target NADPH oxidase p67phox interacts preferentially with Rac2 rather than Rac1.Semantic proximity Read ↗

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Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production.Semantic proximity Read ↗

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Redox regulation of Fcgamma receptor-mediated phagocytosis: implications for host defense and tissue injury.Semantic proximity Read ↗

Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding.Semantic proximity Read ↗

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