Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome.

Blood - 1 Nov 2008

Tian Wei, Li Xing Jun, Stull Natalie D, Ming Wenyu, Suh Chang-Il, Bissonnette Sarah A, Yaffe Michael B, Grinstein Sergio, Atkinson Simon J, Dinauer Mary C

Abstract excerpt

The phagocyte NADPH oxidase generates superoxide for microbial killing, and includes a membrane-bound flavocytochrome b(558) and cytosolic p67(phox), p47(phox), and p40(phox) subunits that undergo membrane translocation upon cellular activation. The function of p40(phox), which binds p67(phox) in resting cells, is incompletely understood. Recent studies showed that phagocytosis-induced superoxide production is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport, Active
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NADPH Oxidases

Share to Phagocytosis

Share to Phagosomes

Share to Phosphatidylinositol Phosphates

Share to Receptors, IgG

Share to Superoxides

Source

Open in PubMed Open full text

Identifiers

PMID: 18711001
DOI: 10.1182/blood-2007-11-126029
PMCID: PMC2572805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome.PMID 18711001Read ↗

The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis.Semantic proximity Read ↗

Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding.Semantic proximity Read ↗

The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.Semantic proximity Read ↗

A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox.Semantic proximity Read ↗

p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox.Semantic proximity Read ↗

Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production.Semantic proximity Read ↗

Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.Semantic proximity Read ↗

Intracellular generation of superoxide by the phagocyte NADPH oxidase: how, where, and what for?Semantic proximity Read ↗

Redox regulation of Fcgamma receptor-mediated phagocytosis: implications for host defense and tissue injury.Semantic proximity Read ↗

Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis.Semantic proximity Read ↗

Activation of the phagocyte NADPH oxidase protein p47(phox). Phosphorylation controls SH3 domain-dependent binding to p22(phox).Semantic proximity Read ↗

Interleukin-4 alters early phagosome phenotype by modulating class I PI3K dependent lipid remodeling and protein recruitment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.