Article
Translational studies of phenotypic probes for the mononuclear phagocyte system and liposomal pharmacology.
The Journal of pharmacology and experimental therapeutics - 1 Dec 2013
Caron Whitney P, Lay John C, Fong Alan M, La-Beck Ninh M, Kumar Parag, Newman Suzanne E, Zhou Haibo, Monaco Jane H, Clarke-Pearson Daniel L, Brewster Wendy R, Van Le Linda, Bae-Jump Victoria L, Gehrig Paola A, Zamboni William C
Abstract excerpt
As nanoparticles (NPs) are cleared via phagocytes of the mononuclear phagocyte system (MPS), we hypothesized that the function of circulating monocytes and dendritic cells (MO/DC) in blood can predict NP clearance (CL). We measured MO/DC phagocytosis and reactive oxygen species (ROS) production in mice, rats, dogs, and patients with refractory solid tumors. Pharmacokinetic studies of polyethylene glycol...
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