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Article

Dissecting partner recognition by an intrinsically disordered protein using descriptive random mutagenesis.

Journal of molecular biology - 23 Sept 2013

Gruet Antoine, Dosnon Marion, Vassena Andrea, Lombard Vincent, Gerlier Denis, Bignon Christophe, Longhi Sonia

Abstract excerpt

In view of getting insights into the molecular determinants of the binding efficiency of intrinsically disordered proteins (IDPs), we used random mutagenesis. As a proof of concept, we chose the interaction between the intrinsically disordered C-terminal domain of the measles virus nucleoprotein (NTAIL) and the X domain (XD) of the viral phosphoprotein and assessed how amino acid substitutions introduced at...

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PMID: 23811056
DOI: 10.1016/j.jmb.2013.06.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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