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Article

Disorder for Dummies: Functional Mutagenesis of Transient Helical Segments in Disordered Proteins.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Daughdrill Gary W

Abstract excerpt

Most cytosolic eukaryotic proteins contain a mixture of ordered and disordered regions. Disordered regions facilitate cell signaling by concentrating sites for posttranslational modifications and protein-protein interactions into arrays of short linear motifs that can be reorganized by RNA splicing. The evolution of disordered regions looks different from their ordered counterparts. In some cases, selection is...

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PMID: 32696350
DOI: 10.1007/978-1-0716-0524-0_1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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