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Article

Residual Helicity at the Active Site of the Histidine Phosphocarrier, HPr, Modulates Binding Affinity to Its Natural Partners.

International journal of molecular sciences - 6 Oct 2021

Neira José L, Ortega-Alarcón David, Rizzuti Bruno, Palomino-Schätzlein Martina, Velázquez-Campoy Adrián, Falcó Alberto

Abstract excerpt

The phosphoenolpyruvate-dependent phosphotransferase system (PTS) modulates the preferential use of sugars in bacteria. The first proteins in the cascade are common to all organisms (EI and HPr). The active site of HPr involves a histidine (His15) located immediately before the beginning of the first α-helix. The regulator of sigma D (Rsd) protein also binds to HPr. The region of HPr comprising residues...

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Identifiers

PMID: 34639146
DOI: 10.3390/ijms221910805
PMCID: PMC8509676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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