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Article

Dose-dependent diastolic dysfunction and early death in a mouse model with cardiac troponin mutations.

Journal of molecular and cellular cardiology - 1 Sept 2013

Li Yuejin, Zhang Lei, Jean-Charles Pierre-Yves, Nan Changlong, Chen Guozhen, Tian Jie, Jin J-P, Gelb Ira J, Huang Xupei

Abstract excerpt

Our aim was to explore the dose-dependent diastolic dysfunction and the mechanisms of heart failure and early death in transgenic (TG) mice modeling human restrictive cardiomyopathy (RCM). The first RCM mouse model (cTnI(193His) mice) carrying cardiac troponin I (cTnI) R193H mutation (mouse cTnI R193H equals to human cTnI R192H) was generated several years ago in our laboratory. The RCM mice manifested a...

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Identifiers

PMID: 23810866
DOI: 10.1016/j.yjmcc.2013.06.007
PMCID: PMC5394738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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