Article
Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo.
Circulation. Heart failure - 1 Sept 2017
Li Yuejin, Zhu Guangshuo, Paolocci Nazareno, Zhang Pingbo, Takahashi Cyrus, Okumus Nazli, Heravi Amir, Keceli Gizem, Ramirez-Correa Genaro, Kass David A, Murphy Anne M
Abstract excerpt
BACKGROUND: In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament calcium sensitivity and alters calpain-mediated cTnI proteolysis. However, how its hyperphosphorylation affects cardiac function in vivo remains unknown. METHODS AND RESULTS: To address the question, 2 transgenic...
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