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Article

Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants.

Journal of molecular and cellular cardiology - 1 May 2008

Davis Jennifer, Wen Haitao, Edwards Terri, Metzger Joseph M

Abstract excerpt

Restrictive cardiomyopathy (RCM) is a debilitating disease characterized by impaired ventricular filling, reduced ventricular volumes, and severe diastolic dysfunction. Hypertrophic cardiomyopathy (HCM) is characterized by ventricular hypertrophy and heightened risk of premature sudden cardiac death. These cardiomyopathies can result from mutations in the same gene that encodes for cardiac troponin I (cTnI)....

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Identifiers

PMID: 18423659
DOI: 10.1016/j.yjmcc.2008.02.274
PMCID: PMC2443058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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