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Article

Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy.

Journal of molecular and cellular cardiology - 1 Sept 2010

Li Yuejin, Charles Pierre-Yves Jean, Nan Changlong, Pinto Jose Renato, Wang Yingcai, Liang Jingsheng, Wu Gang, Tian Jie, Feng Han-Zhong, Potter James D, Jin J-P, Huang Xupei

Abstract excerpt

Several cardiac troponin I (cTnI) mutations are associated with restrictive cardiomyopathy (RCM) in humans. We have created transgenic mice (cTnI(193His) mice) that express the corresponding human RCM R192H mutation. Phenotype of this RCM animal model includes restrictive ventricles, biatrial enlargement and sudden cardiac death, which are similar to those observed in RCM patients carrying the same cTnI mutation....

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Identifiers

PMID: 20580639
DOI: 10.1016/j.yjmcc.2010.04.017
PMCID: PMC5394742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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