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Article

A point mutation (R192H) in the C-terminus of human cardiac troponin I causes diastolic dysfunction in transgenic mice.

Archives of biochemistry and biophysics - 15 Dec 2006

Du J, Zhang C, Liu J, Sidky C, Huang X P

Abstract excerpt

Cardiac troponin I (cTnI) mutations have been linked to the development of restrictive cardiomyopathy (RCM) in human patients. We modeled one mutation in human cTnI C-terminus, arginine192-->histidine (R192H) by cardiac specific expression of the mutated protein (cTnI(193His) in mouse sequence) in transgenic mice. Heart tissue sections revealed neither significant hypertrophy nor ventricular dilation in...

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Cardiomyopathy, Restrictive
Mutagenesis, Site-Directed
Myocardium
Recombinant Proteins
Structure-Activity Relationship

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ultrasonography

Ventricular Dysfunction, Left

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PMID: 17027633
DOI: 10.1016/j.abb.2006.08.018

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