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Article

Progressive troponin I loss impairs cardiac relaxation and causes heart failure in mice.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2007

Liu Jing, Du Jianfeng, Zhang Chi, Walker Jeffery W, Huang Xupei

Abstract excerpt

Cardiac troponin I (TnI) knockout mice exhibit a phenotype of sudden death at 17-18 days after birth due to a progressive loss of TnI. The objective of this study was to gain insight into the physiological consequences of TnI depletion and the cause of death in these mice. Cardiac function was mo...

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Source

Identifiers

PMID: 17526646
DOI: 10.1152/ajpheart.01379.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17526646-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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