Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Augmented systolic response to the calcium sensitizer EMD-57033 in a transgenic model with troponin I truncation.

American journal of physiology. Heart and circulatory physiology - 1 May 2004

Soergel David G, Georgakopoulos Dimitrios, Stull Linda B, Kass David A, Murphy Anne M

Abstract excerpt

Myocardial stunning is a form of acute reversible cardiac dysfunction that occurs after brief periods of ischemia and reperfusion. In several animal models, stunning is associated with proteolytic truncation of troponin I (TnI). Mice expressing the same proteolytic TnI fragment [TnI-(1-193)] demonstrate cardiac depression with a decreased maximal calcium-activated tension. We therefore hypothesized preferential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiotonic Agents
Share to Hemodynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Contraction

Share to Myocardial Contraction

Share to Myofibrils

Share to Quinolines

Share to Systole

Share to Troponin I

Source

Identifiers

PMID: 14693678
DOI: 10.1152/ajpheart.00170.2003

Genes

EMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Augmented systolic response to the calcium sensitizer EMD-57033 in a transgenic model with troponin I truncation.PMID 14693678Read ↗

Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts--role of myofilament Ca2+ sensitivity increase.Semantic proximity Read ↗

Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo.Semantic proximity Read ↗

Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy.Semantic proximity Read ↗

Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling.Semantic proximity Read ↗

Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy.Semantic proximity Read ↗

The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin I.Semantic proximity Read ↗

Dose-dependent diastolic dysfunction and early death in a mouse model with cardiac troponin mutations.Semantic proximity Read ↗

A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress.Semantic proximity Read ↗

Omecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca2+ Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K.Semantic proximity Read ↗

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts.Semantic proximity Read ↗

Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart.Semantic proximity Read ↗

Removal of the cardiac troponin I N-terminal extension improves cardiac function in aged mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.