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Article

Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2008

Du Jianfeng, Liu Jing, Feng Han-Zhong, Hossain M M, Gobara Nariman, Zhang Chi, Li Yuejin, Jean-Charles Pierre-Yves, Jin Jian-Ping, Huang Xu-Pei

Abstract excerpt

Transgenic mice were generated to express a restrictive cardiomyopathy (RCM) human cardiac troponin I (cTnI) R192H mutation in the heart (cTnI(193His) mice). The objective of this study was to assess cardiac function during the development of diastolic dysfunction and to gain insight into the pathophysiological impact of the RCM cTnI mutation. Cardiac function and pathophysiological changes were monitored in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18408133
DOI: 10.1152/ajpheart.91506.2007
PMCID: PMC2769498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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