Article
A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy.
The Journal of clinical investigation - 15 Jun 1998
Tardiff J C, Factor S M, Tompkins B D, Hewett T E, Palmer B M, Moore R L, Schwartz S, Robbins J, Leinwand L A
Abstract excerpt
Mutations in multiple cardiac sarcomeric proteins including myosin heavy chain (MyHC) and cardiac troponin T (cTnT) cause a dominant genetic heart disease, familial hypertrophic cardiomyopathy (FHC). Patients with mutations in these two genes have quite distinct clinical characteristics. Those wi...
Topics
- Animals
- Base Sequence
- Cardiomyopathy, Hypertrophic
- Heart
- Humans
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Troponin
- Troponin T