Article
Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.
The Journal of cell biology - 9 Jun 2014
Holloway J Kim, Sun Xianfei, Yokoo Rayka, Villeneuve Anne M, Cohen Paula E
Abstract excerpt
Meiotic crossovers (COs) are crucial for ensuring accurate homologous chromosome segregation during meiosis I. Because the double-strand breaks (DSBs) that initiate meiotic recombination greatly outnumber eventual COs, this process requires exquisite regulation to narrow down the pool of DSB intermediates that may form COs. In this paper, we identify a cyclin-related protein, CNTD1, as a critical mediator of this...
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