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Article

Coordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKs.

PLoS genetics - 1 Jan 2013

Liang Fengshan, Richmond Daniel, Wang Yanchang

Abstract excerpt

Because cohesion prevents sister-chromatid separation and spindle elongation, cohesion dissolution may trigger these two events simultaneously. However, the relatively normal spindle elongation kinetics in yeast cohesin mutants indicates an additional mechanism for the temporal control of spindle elongation. Here we show evidence indicating that S-phase CDK (cyclin dependent kinase) negatively regulates spindle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23468650
DOI: 10.1371/journal.pgen.1003319
PMCID: PMC3584997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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