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Article

T cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers.

Haematologica - 1 Mar 2017

Palma Marzia, Gentilcore Giusy, Heimersson Kia, Mozaffari Fariba, Näsman-Glaser Barbro, Young Emma, Rosenquist Richard, Hansson Lotta, Österborg Anders, Mellstedt Håkan

Abstract excerpt

Chronic lymphocytic leukemia is characterized by impaired immune functions largely due to profound T-cell defects. T-cell functions also depend on co-signaling receptors, inhibitory or stimulatory, known as immune checkpoints, including cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and programmed death-1 (PD-1). Here we analyzed the T-cell phenotype focusing on immune checkpoints and activation markers in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27927767
DOI: 10.3324/haematol.2016.151100
PMCID: PMC5394965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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